A double dose of 'Monday Night Football' kicks off with C.J. Stroud and the Houston Texans hosting Baker Mayfield and the Tampa Bay Buccaneers. The hosts are looking for their first win of the 2025 NFL season after stumbling in Week 1 against the Los Angeles Rams 14-9. Meanwhile, the Buccaneers head into NFL Week 2 with a victory under their belts, having held off the Atlanta Falcons 23-20 to start their season. Both teams will be missing a key receiver with Christian Kirk (hamstring) out for Houston and Chris Godwin (foot) out for Tampa Bay.

Kickoff from NRG Stadium is set for 7 p.m. ET. Houston is a 2.5-point favorite in the latest Buccaneers vs. Texans odds, and the over/under for total points scored is 42.5. The Texans are -145 favorites on the money line (risk $145 to win $100), while the Buccaneers are +121 underdogs (risk $100 to win $121). Before making any Texans vs. Buccaneers picks, be sure to see what the SportsLine projection model has to say. 

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The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model is on a 33-17 run on top-rated picks dating back to 2024. Anybody following its NFL betting picks at sportsbooks and on betting sites could have seen strong returns.  

Now, the model has zeroed in on Texans vs. Buccaneers. You can head to SportsLine now to see its picks. Here are several NFL odds and betting lines for Buccaneers vs. Texans:

Why the Buccaneers can cover

The Bucs went 10-7-0 ATS last season and have already covered the spread in their first game of the season. They were arguably lucky to get the win in Week 1 since they didn't generate much yardage, but Mayfield still threw three touchdown passes and rookie receiver Emeka Egbuka shined by catching two of those TDs. Egbuka can help open up the offense by taking some of the attention off of Mike Evans, giving Mayfield options against a Texans defense that allowed 244 passing yards in Week 1. See which team to back at SportsLine. 

Why the Texans can cover

Houston is in a position to rebound after Ka'imi Fairbairn scored all of its Week 1 points with three first-half field goals. Nico Collins can have a bounce-back game by frustrating a Buccaneers defense that allowed the fourth-most passing yards in Week 1 (289 out of 358 yards total). Nick Chubb had 13 carries for 60 yards against the Rams, so he should be firing on all cylinders in his first home game with the Texans. Houston was 7-8-2 ATS in 2024 and covered four times at home. See which team to back at SportsLine. 

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How to make Texans vs. Buccaneers picks

For this NFL Week 2 Monday Night Football game, the model is leaning over the total, and also says one side of the spread hits almost 60% of the time. See what it is at SportsLine.

Who wins Buccaneers vs. Texans, and which side of the spread hits almost 60% of the time? Visit SportsLine now to see which side of the Texans vs. Buccaneers spread you need to jump, all from the model that is 33-17 on top-rated picks since 2024, and find out.