The Philadelphia Eagles look to start their season 3-0 and gain early control of the NFC East division when they take on the Los Angeles Rams on Sunday. The Eagles, who have won the division in four of the past eight years, are looking to be the first repeat winner in the division since they accomplished the feat in four consecutive years from 2001-04. They already have a one-game lead over Washington and Dallas, and two over the winless Giants. The defending Super Bowl champs are coming off a 20-17 win over the Chiefs in Week 2. The latest Week 3 NFL odds list the Eagles at -3.5, with an over/under at 44.5, after Philly beat L.A. in both the regular and postseason in 2024.

In a game featuring the smallest NFL line of the week and of the season, Aaron Rodgers and the Pittsburgh Steelers (-1.5) look to rebound when they take on the New England Patriots. Pittsburgh is coming off a 31-17 loss to the Seattle Seahawks. Other tight NFL lines include Cowboys vs. Bears (+1.5), Cardinals vs. 49ers (-2.5), Texans vs. Jaguars (-1.5) and Bengals vs. Vikings (-3). Which team has value to include in Week 3 NFL bets, and which side of the NFL spread should you target? 

Before locking in any Week 3 NFL picks or NFL parlays, be sure to see the NFL predictions and betting advice from SportsLine's proven computer model.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model is on a sizzling 37-17 run on top-rated picks dating back to 2024. Anybody following its NFL betting picks at sportsbooks and on betting sites could have seen strong returns.

Now, the model has scoured the Week 3 NFL odds and locked in five confident NFL best bets. If you successfully parlay its picks, you'd be looking at a massive payout of around 25-1. You can only see the model's Week 3 NFL picks at SportsLine, 

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Top Week 3 NFL picks

After simulating every game 10,000 times, the model is high on the Philadelphia Eagles (-3.5, 44.5) to cover against the Los Angeles Rams. Philadelphia is the defending Super Bowl champion. The Eagles won both meetings with the Rams last year, including a 28-22 win over the Rams in last year's NFC Divisional round on Jan. 19. The Eagles are led by Jalen Hurts, who is in his sixth year in the league. In 15 games last season, Hurts completed 68.7% of his passes for 2,903 yards and 18 touchdowns with 12five interceptions. He also rushed 150 times for 630 yards and 14 touchdowns.

Among the many weapons the Eagles offense features include running back Saquon Barkley, who rushed 345 times for 2,005 yards (5.8 average) and 13 touchdowns. He also caught 33 passes for 278 yards (8.4 average) and two scores. The Eagles have won the NFC East title in two of the past three seasons, and the model has them covering in well over 60% of simulations. See which other NFL parlay picks to make here and bet the Eagles to cover here:

How to make Week 3 NFL parlays

The model also jumped on four other NFL matchups where it says the line is way off, including backing an underdog that it says will not only cover, but win outright. You can only see the model's Week 3 NFL best bets and NFL parlay at SportsLine.

What are the model's top Week 3 NFL picks, and which NFL matchups should you target for an epic 25-1 payout? Visit SportsLine now to see the Week 3 NFL best bets from a model on an 37-17 run on top-rated picks, and find out.