Eight interconference matchups are featured on the Week 4 NFL schedule, including one being played in Dublin, Ireland, when the Minnesota Vikings battle Aaron Rodgers and the Pittsburgh Steelers (+2.5). There are also three divisional clashes, including two on Sunday with the Jets facing the Dolphins (-2.5) and Titans meet the Texans (-7). The slimmest Week 4 NFL spread is between the Bears and Raiders (+1.5).

Who should you back in each of the games on the Week 4 NFL schedule, and how should you handle all your NFL money line, NFL over/under and NFL against the spread spread picks? Before making any Week 4 NFL picks or Week 4 NFL score predictions, you need to see the NFL against the spread, NFL over/under, and NFL money-line predictions powered by the SportsLine computer simulation model.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model is on a sizzling 39-19 run on top-rated picks dating back to 2024. Anybody following its NFL betting picks at sportsbooks and on betting sites could have seen strong returns.

For Week 4 NFL betting, the model has evaluated the NFL odds and provided picks for all 16 games. You can only see the simulation model's predictions for the Week 4 NFL schedule here. 

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Week 4 NFL score predictions 

After analyzing every game in Week 4, the model says the Commanders beat the Falcons 29-19, covering comfortably as 1.5-point road favorites in a game the model projects will go Over the total (45.5). Despite the possibility that Jayden Daniels (knee), who is considered day-to-day, misses his second consecutive game, the Commanders are confident backup Marcus Mariota can lead them past a reeling Falcons team. Atlanta is coming off a 30-0 loss to the Carolina Panthers.

Mariota was solid in a 41-24 win over the Las Vegas Raiders in Week 3. He completed 15 of 21 passes (71.4%) for 207 yards and one touchdown. He also carried six times for 40 yards and one touchdown. Tight end Zach Ertz is one of the Commanders' top pass catchers with 12 receptions for 128 yards (10.7 average) and two touchdowns. See the model's other Week 4 predictions and football picks at SportsLine.

How to make Week 4 NFL score predictions

The model has generated two highly-coveted A-graded picks for Week 4 that you need to see before making any NFL bets. You can only see the model's picks and analysis at SportsLine.

Who wins and covers each Week 4 NFL game, and which A-graded picks should you target now? Visit SportsLine now to see the top NFL against the spread, over/under, and moneyline picks, all from the computer simulation model that is up over $7,000 since its inception, and find out.