Thursday, September 25 marks the beginning of another week of NFL with the Arizona Cardinals hosting the Seattle Seahawks on Thursday Night Football, and sports bettors can use the latest DraftKings promo code, which offers new users $200 in bonus bets instantly and over $200 off NFL Sunday Ticket. According to the latest Seahawks vs. Cardinals odds at DraftKings Sportsbook, Seattle is favored by 1.5 points, while the over/under for total points scored is 43.5, down a field goal from the opener.

The Mets and Cubs have played in a pair of high-scoring games to begin their series, and the SportsLine model expects that to continue with New York fighting to hold onto its final Wild Card position. The model has Cubs vs. Mets Over 7.5 runs scored among its Thursday best bets at DraftKings Sportsbook, as the two teams have averaged 14.5 runs per game over their first two contests. For NFL, the model has the Cardinals covering the 1.5-point spread as underdogs against the Seahawks on TNF among its Thursday best bets. Claim the latest DraftKings promo code here, where new users get $200 in bonus bets and $200 off NFL Sunday Ticket: 

Check out our DraftKings promo code review for full details.

The SportsLine Projection Model simulates every MLB game 10,000 times. It enters the final weeks of the 2025 MLB regular season a profitable 34-28 on top-rated MLB money-line picks. It has excelled making home run prop picks this season, returning more than 25 units of profit. For the NFL, the model is on a sizzling 39-19 run on top-rated picks dating back to 2024. Anybody following its MLB betting picks or NFL betting picks at sportsbooks and on betting sites could have seen strong returns.

Thursday best bets: 

• Mets vs. Cubs Over 7 total runs (-111)
• Blue Jays vs. Red Sox Over 8 total runs (-112)
• Cardinals (+1.5) vs. Seahawks (-110)

Combining the model's three picks into a Thursday parlay at DraftKings would result in a payout of +586 (risk $100 to win $586). Bet it at DraftKings here:

Mets vs. Cubs Over 7.5 total runs (-111)

The Cubs and Mets have gone well Over this number in each of the first two games of their series, with a 9-7 Mets win on Tuesday followed by a 10-3 Cubs victory on Wednesday. Despite the loss, Francisco Alvarez homered for the second straight game for the Mets, who have a top-10 offense in baseball at 4.75 runs per game. Juan Soto also hit his 43rd home run of the season for New York. The Cubs are eighth in scoring at 4.85 runs per contest. Michael Busch hit his 31st home run of the season for Chicago on Wednesday. The Mets are starting rookie Nolan McLean, who has a 1.27 ERA over his first seven starts, but the 24-year-old allowed a career-high three runs (although only one earned) against the Nationals on Saturday. The Cubs are starting Shota Imanaga, who has a 4.91 ERA over four September starts. The model projects the Over to hit in 65.6% of simulations in a 7:40 p.m. ET start. 

Blue Jays vs. Red Sox Over 8 total runs (-112)

Between the Blue Jays' recent struggles and the Yankees' surge, Toronto and New York are tied for first place in the American League East entering Thursday. While the Yankees have had an easier week with the last-place White Sox, the Blue Jays and Red Sox are two teams likely to make the postseason, and they've been playing high-stakes baseball throughout the week. Both teams have top-10 offenses in baseball, with the Red Sox ranking fifth at 4.91 runs per game and the Blue Jays seventh at 4.87 runs per contest. Toronto is utilizing a bullpen game on Thursday, while Boston is starting Brayan Bello, who has a 5.85 ERA in four September starts. The model projects the Over to hit in 61.5% of simulations.

Cardinals (+1.5) vs. Seahawks (-110)

Seattle has dominated this matchup, winning all six head-to-head contests over the last three years, but with Geno Smith gone and Sam Darnold taking over as QB1, this isn't the same Seahawks team as the last few seasons. Although Seattle is fifth in scoring at 29.3 points per game, Arizona has the No. 5 scoring defense (17 ppg allowed). The Cardinals are 1-0 at home this season, defeating the Panthers, 27-22, behind 220 passing yards from Kyler Murray and two forced turnovers. Seattle is third in the NFL in rushing rate, while the Cardinals rank fourth in rushing yards allowed per game, as Arizona could take away Seattle's biggest strength. The model projects the Cardinals to cover the spread in 51% of simulations for a Thursday Night Football contest at home set for 8:15 p.m. ET.

Want more MLB picks and NFL picks for Thursday, September 25?

You've seen the model's Thursday best bets. Now, get against the spread, total and money-line picks for every Thursday MLB contest, along with college football odds and Week 4 NFL games, all from the model that's simulated every game 10,000 times. 

Also at SportsLine:

You can also see Thursday MLB picks from SportsLine expert Bruce Marshall, who is 161-142-3 (+3377) over his last 306 MLB picks. Visit SportsLine to see his Thursday MLB best bets.