The Monday MLB schedule features several notable MLB matchups, but only 10 total games. One of the top matchups of the day is White Sox vs. Blue Jays at 7:40 p.m. ET in Chicago. The Blue Jays are red-hot and have used their current eight-game winning streak to jump into first place in the American League East standings. Toronto is listed as a -167 favorite (risk $167 to win $100) on the money line in the latest Blue Jays vs. White Sox odds. The SportsLine Projection Model is calling for a close Blue Jays win, with Chicago's Andrew Benintendi and Toronto's Alejandro Kirk going Over 0.5 total RBI at +163 and +156 odds, respectively. 

Another notable matchup on Monday is Red Sox vs. Rockies in Boston at 7:10 p.m. ET. The Red Sox are riding a three-game winning streak and looking to claw their way back into the AL East race. Richard Fitts (0-3, 4.50 ERA) is set to start for Boston, while Austin Gomber (0-1, 5.49 ERA) will be on the mound for Colorado. SportsLine's model is backing Boston to win on the money line at -229 odds. Before making any other MLB picks or building any MLB parlays, you'll want to see the MLB predictions and betting advice from SportsLine's proven computer model. You can also check out our MLB prop picks and MLB home run picks for Monday.

The SportsLine Projection Model simulates every MLB game 10,000 times. It enters Week 16 of the 2025 MLB season 45-38 on top-rated MLB picks. It has excelled making home run prop picks this season, returning more than 28 units of profit. Anybody following at sportsbooks and on betting apps could have seen strong returns.

The model has broken down the MLB odds for Monday and just revealed its top picks and MLB player props. Combining the model's four picks into an MLB parlay would result in a payout of +1572 (risk $100 to win $1,572). New users can even take advantage of the DraftKings promo code offering $150 in bonus bets instantly with a $5 wager.

Here are its best bets for the MLB slate on Monday.

• Andrew Benintendi Over 0.5 total RBI (+163)
• Alejandro Kirk over 0.5 total RBI (+156)
• Boston Red Sox (-229) on the money line vs. Colorado Rockies
• Cincinnati Reds (-136) on the money line vs. Miami Marlins
• Combine these picks for a shot at a +1572 payout (odds subject to change)  

Andrew Benintendi Over 0.5 total RBI (+163)

Benintendi and the White Sox host the red-hot Blue Jays in the first game of their series on Monday. The 31-year-old outfield enters Monday batting .230 with 10 home runs and 34 RBI. SportsLine gives this pick an edge of 0.2 based on the projection of 0.7 RBI for Benintendi and the consensus line of 0.5.

Alejandro Kirk over 0.5 total RBI (+156)

Kirk is having a breakout season for Toronto and establishing himself as one of the better offensive catchers in the American League. The 26-year-old enters Monday batting .301 with seven home runs and 41 RBI. SportsLine gives this pick an edge of 0.3 based on the projection of 0.8 RBI for Kirk and the consensus line of 0.5.

Boston Red Sox (-229) on the money line vs. Colorado Rockies

Boston enters this matchup riding a three-game winning streak, while the Rockies have the worst record in the Majors. Neither side projects to have a favorable pitching matchup, with Richard Fitts (0-3, 4.50 ERA) set to start for Boston and Austin Gomber (0-1, 5.49 ERA) slated to start for Colorado. The SportsLine Projection Model is predicting a final score of 5.6-4.3 in the Boston's favor, with Rerd Sox winning in 70% of computer simulations.

Cincinnati Reds (-136) on the money line vs. Miami Marlins

The Reds host the Marlins at 7:10 p.m. on Monday in a matchup between teams that need to get hot in the second half of the season to make a run at the National League Playoffs. The Reds are scheduled to start Brady Singer (7-6, 4.36 ERA), while the Marlins will have Janson Junk (2-1, 3.62 ERA) on the mound. The SportsLine Projection Model is predicting a final score of 5.3-4.6 in the Reds' favor, with Cincinnati winning in 63% of computer simulations.

Want more MLB picks for today?

You've seen some of the model's MLB best bets for Monday. Now, get run line, total and money-line picks for every game here, all from the model that's simulated every game 10,000 times. 

Also at SportsLine:
You can also see today's top MLB picks from expert Matt Severance, who's on a sizzling 41-17 roll on his last 58 MLB picks. Visit SportsLine to see his best plays for today, all from the expert who's up almost 10 units.