The New York Yankees will look to extend their winning streak to five games when they battle the Chicago Cubs in a key interleague series starting on Friday. Chicago is coming off an 8-1 win over the Minnesota Twins on Thursday, while New York rallied for a 6-5 10-inning victory over the Seattle Mariners. The Cubs (55-38), who are first in the National League Central, are 25-22 on the road in 2025. The Yankees (52-41), who are second in the American League East, are 29-17 on their home field this season. Aaron Judge is at +145 to hit a home run in the latest MLB prop odds.

First pitch from Yankee Stadium in New York is set for 7:05 p.m. ET. The Yankees have won seven of the last 10 meetings with the Cubs. New York is a -178 favorite on the money line (risk $178 to win $100) in the latest Cubs vs. Yankees odds from DraftKings Sportsbook, with Chicago the +149 underdog. The total number of runs Vegas thinks will be scored, or the over/under, is 9. Before making any Yankees vs. Cubs picks, be sure to see the MLB predictions and betting advice from SportsLine's proven computer model.

The SportsLine Projection Model simulates every MLB game 10,000 times. It enters Week 16 of the 2025 MLB season 45-38 on top-rated MLB picks. It has excelled making home run prop picks this season, returning more than 28 units of profit. Anybody following at sportsbooks and on betting apps could have seen strong returns.    

Now, the model has set its sights on Cubs vs. Yankees and just locked in its picks and MLB predictions. You can head to SportsLine now to see the model's picks. Here are several MLB odds and betting lines for Yankees vs. Cubs, which you can get in on with a DraftKings promo code or a FanDuel promo code.

Why the Yankees can win

Left-handed pitcher Carlos Rodon (9-6, 3.30 ERA) is expected to get the start for New York. In 19 games, all starts, he has pitched 111.2 innings, allowing 75 hits, 41 earned runs and 40 walks, while striking out 127. He received a no-decision in a 5-4 loss to the Cincinnati Reds on June 24. In six innings, he allowed four hits and one walk with five strikeouts.

Right fielder Aaron Judge helps power the New York offense. In 93 games, he is hitting .356 with 22 doubles, two triples, 34 homers and 77 RBI. He had a double and two RBI in Wednesday's 9-6 win over the Mariners. He was 2-for-5 with a solo home run in a 10-3 win over Seattle on Tuesday. See which team to back at SportsLine.

Why the Cubs can win

Right-hander Chris Flexen (5-0, 0.83 ERA) is expected to be the opener on Friday for Chicago. It will be his first start of the year. In 17 games, he has pitched 32.2 innings, allowing three earned runs and eight walks with 17 strikeouts. In his last outing, an 8-6 loss to the St. Louis Cardinals on Tuesday, he pitched 3.2 innings, allowing four hits and one earned run with two strikeouts.

Right fielder Kyle Tucker continues to help power the Chicago offense. In 92 games this season, he is batting .284 with 19 doubles, four triples, 17 homers and 55 RBI. He has hits in five consecutive games. In Thursday's win over the Twins, he doubled in five at-bats. He was 1-for-2 with a walk and three RBI in an 11-0 win over the St. Louis Cardinals on Sunday. See which team to back at SportsLine. 

How to make Cubs vs. Yankees picks

SportsLine's model is leaning Over on the total, projecting 9.8 combined runs, and it says one side of the money line has all the value. You can head to SportsLine to see the model's MLB picks. 

So who wins Cubs vs. Yankees, and which side of the money line has all the value? Visit SportsLine now to see which side you need to jump on, all from the model that has crushed its MLB picks, and find out.